Undergraduate Catalog 2005- 2006

Biochemical Pharmacology

Department of Pharmacology and Toxicology

School of Medicine and Biomedical Sciences
102 Farber Hall
South Campus
Buffalo, NY 14214-3000

Phone: 716.829.2800
Fax: 716.829.2801
Web: www.smbs.buffalo.edu/pmy

Vijay C. Swamy
Director of Undergraduate Studies
97 Farber Hall
716.829.2194
vswamy@buffalo.edu

About the Program

Pharmacology, simply defined, is the study of the interaction of drugs with living systems. This subject, which has a fascinating history and continues to be relevant in modern times, deals with a number of questions, for example: What is the molecular site of action? What are the changes caused by a drug in the normal function of tissues and organs? What is the relationship between the dose of a drug and its effect? How do drugs produce their effects? What happens to drugs once they enter the body? Since a drug is traditionally defined as a chemical that interacts with living systems, this subject has a very broad relevance from its obvious importance in the diagnosis and treatment of disease to the impact of abuse substances or environmental chemicals on societies. One of the strengths of the department is its focus on the use of molecular biology and gene cloning methods to develop the pharmacological agents of the future. Students in the department are encouraged to do research projects with the faculty who have interdisciplinary research interests in molecular biology, protein biochemistry, electrophysiology, and protein biophysics.

The broad academic background provides students with a wide array of career opportunities. Many graduates enter medical or dental schools or pursue graduate studies in pharmacology or other biological and biochemical sciences. Pharmacology graduates find employment in technical, production/analytical, or sales positions as research scientists or drug information specialists in the pharmaceutical industry, government, university laboratories, and hospitals. Students have also pursued careers in law and management following completion of their BS degree in pharmacology. The program is available only to registered biochemical pharmacology (BCP) majors at the University at Buffalo.

Degree Options

In addition to the BS program, the department offers a combined BS/MS degree that provides the laboratory research training and advanced courses needed for entry-level professional positions in the pharmaceutical industry and in academia. In this combined degree program, students have the opportunity to earn the combined degree in five years versus the usual six years needed to obtain both a BS and an MS degree. The program is available only to registered University at Buffalo students during their junior year.

Transfer Policy

Transfer students should obtain admission to the university through the Office of Admissions before applying to the Department of Pharmacology and Toxicology. Students must complete their university application (which includes sending official transcripts of the fall semester work) prior to March 15th. The department will evaluate prerequisite courses previously taken as possible substitutes for required courses.

Biochemical Pharmacology - B.S.

Acceptance Criteria

Minimum GPA of 2.5 in prerequisite courses.
Minimum GPA of 2.0 in required courses.

Advising Notes

Approximately 15-20 students are selectively admitted to the program each fall after completion of the prerequisites. Students should apply for admission while completing the departmental prerequisites--preferably during the middle of the sophomore year, but no later than March 15th. Applicants should bring a copy of their current UB DARS report directly to the Department of Pharmacology and Toxicology.

Prerequisite Courses

BIO 200 Evolutionary Biology
BIO 201 Cell Biology
CHE 101 General Chemistry or CHE 105 Chemistry: Principles and Applications
CHE 102 General Chemistry or CHE 106 Chemistry: Principles and Applications
CHE 201 Organic Chemistry
CHE 202 Organic Chemistry
MTH 121 Survey of Calculus and Its Applications I or MTH 141 College Calculus I
MTH 122 Survey of Calculus and Its Applications II or MTH 142 College Calculus II
PHY 101/PHY 151 College Physics I/Lab* or PHY 107 General Physics I
PHY 102/PHY 152 College Physics II/Lab* or PHY 108/PHY 158 General Physics II/Lab*

Required Courses

BCH 403 Principles of Biochemistry
BCP 405 Principles of Pharmacology
BCP 406 Principles of Pharmacology
BCP 409 Experimental Pharmacology
BIO 302 Introduction to Molecular Biology
MCH 311 The Chemistry of Drug Action
PGY 451 Human Physiology I
PGY 452 Human Physiology II
Science electives**

Summary
Total required credit hours for the major...88-99

See Baccalaureate Degree Requirements for general education and remaining university requirements.

Recommended Sequence of Program Requirements

FIRST YEAR
Fall BIO 200; CHE 101 or CHE 105; MTH 121 or MTH 141
Spring BIO 201; CHE 102 or CHE 106; MTH 122 or MTH 142

SECOND YEAR
Fall CHE 201; PHY 101/PHY 151* or PHY 107
Spring CHE 202; PHY 102/PHY 152* or PHY 108/PHY 158*

THIRD YEAR
Fall BCH 403, MCH 311, PGY 451
Spring PGY 452, science electives**

FOURTH YEAR
Fall BCP 405, BIO 302, science electives**
Spring BCP 406, BCP 409, science electives**

*Only one (1) physics lab is required.

**15-25 credit hours of science electives are required; CHE 349 Physical Chemistry for Life Sciences is strongly recommended.

Electives and Course Groupings

Students may choose from the following science electives:

ANA 113, APY 107, APY 275, APY 276, BIO 319, BIO 328, BIO 401, BIO 461, BIO 468, BPH 303, CHE 214, CHE 349, CHE 412, CSE 101, MIC 301, MIC 412, MIC 401, MT 402, NTR 108, NTR 401, PGY 405, PGY 412, PHI 337, STA 119, STA 427


Biochemical Pharmacology - B.S./M.S.

Acceptance Criteria

Minimum GPA of 3.0 overall.
Three (3) supportive letters of recommendation from the faculty.
A personal statement from the student.

Advising Notes

Applications are accepted only from registered University at Buffalo students during their junior year. The Graduate Record Exam is not a requirement for admission. Forms and applications should be filed by June 1. Students are encouraged to apply on-line.

Applications must be approved by the both the undergraduate and graduate admission committees.

Prerequisite Courses

BIO 200 Evolutionary Biology
BIO 201 Cell Biology
CHE 101 General Chemistry or CHE 105 Chemistry: Principles and Applications
CHE 102 General Chemistry or CHE 106 Chemistry: Principles and Applications
CHE 201 Organic Chemistry
CHE 202 Organic Chemistry
MTH 121 Survey of Calculus and Its Applications I or MTH 141 College Calculus I
MTH 122 Survey of Calculus and Its Applications II or MTH 142 College Calculus II
PHY 101/PHY 151 College Physics I/Lab* or PHY 107 General Physics I
PHY 102/ PHY 152 College Physics II/Lab* or PHY 108/PHY 158 General Physics II/Lab*

Required Courses

BCH 403 Principles of Biochemistry
BCP 511 Principles of Pharmacology I
BCP 512 Principles of Pharmacology II
BIO 302 Introduction to Molecular Biology
BMS 501 Cell Biology I
BMS 505 Cell Biology IIA
BMS 506 Cell Biology IIB
GSC 640 Graduate Research Ethics
MCH 311 The Chemistry of Drug Action
PGY 451 Human Physiology I
PGY 452 Human Physiology II
PMY 550 Pharmacology Seminar
Research credits**
Science electives***

Summary
Total required credit hours for the undergraduate portion...77-81

See Baccalaureate Degree Requirements for general education and remaining university requirements.

Recommended Sequence of Program Requirements

FIRST YEAR
Fall BIO 200; CHE 101 or CHE 105; MTH 121 or MTH 141
Spring BIO 201; CHE 102 or CHE 106; MTH 122 or MTH 142

SECOND YEAR
Fall CHE 201; PHY 101/PHY 151* or PHY 107
Spring CHE 202; PHY 102/PHY 152* or PHY 108/PHY 158*

THIRD YEAR
Fall BCH 403, MCH 311, PGY 451, science elective***
Spring PGY 452, science electives***

FOURTH YEAR
Fall BCP 511, BIO 302, thesis research**, graduate science elective***
Spring BCP 512, GSC 640, thesis research**

FIFTH YEAR
Fall BMS 501, PMY 550, thesis research**
Spring BMS 505, BMS 506, thesis research**
Accepted Thesis

*Only one(1) physics lab is required.

**12-22 credit hours of research are required.

***15-19 credit hours of science electives are required; some courses may include a laboratory (4 cr).


Biochemical Pharmacology - Minor

About the Minor

The minor is suited to a wide variety of science and nonscience majors interested in acquiring an introductory understanding of drug action.

Acceptance Criteria

Applications should be made when the student has completed the prerequisite courses or is in the process of completing them during the semester when the application is made.

Minimum GPA of 2.5 in prerequisite courses.
Minimum GPA of 2.0 overall in minor to graduate.

Prerequisite Courses

BIO 200 Evolutionary Biology and BIO 201 Cell Biology
CHE 101-CHE 102 General Chemistry
CHE 201-CHE 202 Organic Chemistry

Required Courses

BCH 403 Principles of Biochemistry
BCP 302 Introduction to Pharmacology
PGY 300 Human Physiology
One elective science course selected with approval of program director



Course Descriptions

BCP 302 Introduction to Pharmacology

Credits:  4
Semester: F
Prerequisites:  PGY 300, PGY 451
Corequisites:  None
Type:  LEC

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Introductory survey of the major drug groups commonly used in therapeutics. Presents the scientific bases of drug action and the utilization of their properties in the diagnosis and treatment of disease. Content and instruction is largely directed toward students in biomedical and life sciences programs (e.g., nursing and exercise science). Prerequisites include a strong background in basic sciences (chemistry and biology) and physiology (PGY 300 or equivalent).

 

BCP 405 Principles of Pharmacology

Credits:  4
Semester: F
Prerequisites:  BCH 403, PGY 451, PGY 452
Corequisites:  None
Type:  LEC/REC

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Explores principles of drug action on biological systems, action mechanism of each agent class on specific organ systems, a review and extension of pertinent physiologic concepts of that system, chemical structure–drug activity relationships, sites of action, metabolic patterns of principal drugs, and therapeutic and toxicologic aspects. Dual-listed with BCP 511.


BCP 406 Principles of Pharmacology

Credits:  4
Semester: Sp
Prerequisites:  BCP 405
Corequisites:  None
Type:  LEC/REC

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Explores principles of drug action on biological systems, action mechanism of each agent class on specific organ systems, a review and extension of pertinent physiologic concepts of that system, chemical structure–drug activity relationships, sites of action, metabolic patterns of principal drugs, and therapeutic and toxicologic aspects. Dual-listed with BCP 512.

 

BCP 408 Undergraduate Research Participation in Biochemical Pharmacology

Credits:  1 - 12
Semester: F Sp
Prerequisites:  None
Corequisites:  None
Type:  LAB/TUT

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The content of this course is variable and therefore it is repeatable for credit. The University Grade Repeat Policy does not apply.

Direct involvement in original research involving a literature search and laboratory work.


BCP 409 Experimental Pharmacology

Credits:  3
Semester: Sp
Prerequisites:  BCP 405
Corequisites:  BCP 406
Type:  LEC/LAB

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Covers fundamental pharmacologic techniques; complements instruction in BCP 405. Priority goes to BCP majors.

 

BCP 499 Independent Study

Credits:  1 - 8
Semester: F Sp
Prerequisites:  None
Corequisites:  None
Type:  TUT

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Involves a literature search and library work on a current topic in pharmacology. Includes interdisciplinary projects, such as analyses of trends in drug use, toxicological projects, and applied clinical aspects.


Updated: Nov 16, 2005 10:47:22 AM

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