## Bioinformatics And Computational Biology

#### Department of Biological Sciences

College of Arts and Sciences

109 Cooke Hall

North Campus

Buffalo, NY 14260-1300

Phone: 716.645.2363

Fax: 716.645.2975

Web: www.biology.buffalo.edu

**James R. Lafountain**

Director of Undergraduate Studies

#### Department of Computer Science and Engineering

School of Engineering and Applied Sciences

201 Bell Hall

North Campus

Buffalo, NY 14260-2000

Phone: 716.645.3180

Fax: 716.645.3464

Web: www.cse.buffalo.edu

**Jaynee Straw**

Program Undergraduate Advisor

#### Department of Mathematics

College of Arts and Sciences

244 Mathematics Building

North Campus

Buffalo, NY 14260

Phone: 716.645.6284

Fax: 716.645.5039

Web: www.math.buffalo.edu

**John Ringland**

Director of Undergraduate Studies

#### Department of Physiology and Biophysics

School of Medicine and Biomedical Sciences

124 Sherman Hall

South Campus

Buffalo, NY 14214-3078

Phone: 716.829.2738

Fax: 716.829.2344

Web: www.smbs.buffalo.edu/phys/

**Shinpei Ohki**

Director of Undergraduate Biophysics Programs

#### About the Program

The Bioinformatics and Computational Biology (BCB) program is an interdisciplinary program that involves the application of mathematics and computing to the study of genes and proteins; computational biology addresses more general questions involving computing applied to cellular and sub-cellular structures. As such, students in bioinformatics and computational biology integrate topics of applied mathematics, computer science, and biology into specialties as diverse as genetics, biophysics, computational science, and microbiology. The program prepares students for graduate studies either in a bioinformatics-related field or in a traditional discipline, as well as for immediate entry into the job market.

Students in the BCB program select a major from among four concentrations, offered in the Departments of Biological Sciences, Physiology and Biophysics, Computer Science and Engineering, and Mathematics. Students in the program complete a full major in their area of concentration and also take additional courses important to bioinformatics in disciplines that complement their concentration. All students take courses in calculus, statistics, molecular biology, organic chemistry, and databases, as well as a core course in bioinformatics. In addition, students enroll in a bioinformatics seminar and complete an interdisciplinary project during their senior year. Through these capstone events and the bioinformatics course, students integrate different fields of study into a coherent whole.

#### Acceptance Information

Students may indicate a preference to major in bioinformatics at any time, although acceptance into the major occurs only after a review of a student’s progress at the end of four semesters of coursework. Because of the significant academic demands of this program, acceptance into the bioinformatics program requires an overall minimum GPA of 2.5, and a minimum GPA of 3.0 in the prerequisite courses: BIO 205, CHE 101, CHE 102, CSE 115, CSE 116, MTH 141, and MTH 142. In exceptional circumstances, a student who wishes to major in bioinformatics may request a waiver or modification of the acceptance requirements. It is recommended that the prerequisite courses be completed by the end of the fourth semester; students with advanced placement credit may complete these courses earlier and then request acceptance into the program. Students are expected to maintain a minimum GPA of 3.0 in all major courses (a student may request a waiver or modification of this GPA requirement in exceptional cases). Students who follow the BCB program of study for several semesters but, for whatever reason, decide not to complete those requirements can complete a traditional major in their area of concentration.

#### Academic Requirements

The core course requirements shared by all concentrations are:

BIO 205; BIO 302 or BIO 319; BIO 400 (BIO 205 will serve as prerequisite for BIO 302)

CHE 101, CHE 102, CHE 201 (or CHE 203 for non-BIO students),

CSE 115, CSE 116, CSE 250, CSE 462 (BIO students take either CSE 462 or CSE/MTH 337; CSE 250 will serve as a prerequisite for CSE 462),

MTH 141, MTH 142, MTH 241, MTH 306, MTH 309, MTH 411(BIO and BPH students are exempt from MTH 241 and MTH 306)

MTH/CSE 191, MTH/CSE 337 or MTH/CSE 437-MTH/CSE 438 (BIO students take either CSE 462 or CSE/MTH 337; BPH students take BPH 410)

Senior Seminar

Senior Project

For the senior project, students work with faculty from the department of their concentration. Personnel associated with the Center of Excellence in Bioinformatics may offer additional assistance and guidance to the students.

### Bioinformatics and Computational Biology - B.S.

### Concentration in Biology

#### Acceptance Criteria

Minimum GPA of 2.5 overall.

Minimum GPA of 3.0 in the prerequisite courses.

#### Advising Note

Students must maintain a minimum GPA of 3.0 in all major courses to graduate.

#### Prerequisite Courses

BIO 205 Fundamentals of Biological Chemistry

CHE 101 General Chemistry I

CHE 102 General Chemistry II

CSE 115 Introduction to Computer Science for Majors I

CSE 116 Introduction to Computer Science for Majors II

MTH 141 College Calculus I

MTH 142 College Calculus II

#### Required Courses

BIO 200 Evolutionary Biology

BIO 201 Cell Biology

BIO 215 Fundamentals of Biological Chemistry Lab

BIO 309 Ecology

BIO 319 Genetics

BIO 329 Genetics Lab

BIO 328 General Physiology

BIO 367 Developmental Biology

BIO 370 Developmental Biology Lab

BIO 400 Bioinformatics

CHE 201 Organic Chemistry I

CHE 202 Organic Chemistry II

CSE 250 Algorithms and Data Structures

CSE 191/MTH 191 Introduction to Discrete Mathematics

MTH 337/CSE 337 Introduction to Scientific Computing or CSE 462 Database Concepts or MTH 437/CSE 437 Introduction to Numerical Analysis

MTH 309 Introduction to Linear Algebra

MTH 411 Probability

PHY 107 General Physics I

PHY 108 General Physics II

PHY 158 General Physics Lab

Senior Project

Senior Seminar

**Summary**

Total required credit hours for the major (concentration in bioinformatics-biology)...104

**See Baccalaureate Degree Requirements for general education and remaining university requirements.**

#### Recommended Sequence of Program Requirements

FIRST YEAR

Fall BIO 200, CHE 101, MTH 141

Spring BIO 201, CHE 102, MTH 142

SECOND YEAR

Fall BIO 309, CHE 201, CSE 115, CSE 191/MTH 191

Spring BIO 205, BIO 215, CHE 202, CSE 116

THIRD YEAR

Fall BIO 319, BIO 329, MTH 309

Spring BIO 367, BIO 370, CSE 250

FOURTH YEAR

Fall MTH 411, PHY 107, Senior Seminar

Spring BIO 328, BIO 400; MTH 337/CSE 337 or CSE 462 or MTH 437/CSE 437; PHY 108, PHY 158, Senior Project

### Bioinformatics and Computational Biology - B.S.

### Concentration in Biophysics

#### Acceptance Criteria

Minimum GPA of 2.5 overall.

Minimum GPA of 3.0 in the prerequisite courses.

#### Advising Note

Students must maintain a minimum GPA of 3.0 in all major courses to graduate.

#### Prerequisite Courses

BIO 205 Fundamentals of Biological Chemistry or BCH 403 Principles of Biochemistry

CHE 101 General Chemistry I

CHE 102 General Chemistry II

CSE 115 Introduction to Computer Science

CSE 116 Introduction to Computer Science

MTH 141 College Calculus I

MTH 142 College Calculus II

#### Required Courses

BIO 201 Cell Biology

BIO 302 Introduction to Molecular Biology or BIO 319 Genetics

BIO 400 Bioinformatics

BPH 303 Principles of Biophysics

BPH 402 Biophysics Problems for Undergraduates

BPH 405 Biophysics Basics: Processes

BPH 410 Introductory Quantitative Biology

BPH 458 Experimental Biophysics*

CHE 203 Organic Chemistry

CHE 319 Physical Chemistry or CHE 349 Physical Chemistry for Life Sciences

CSE 250 Algorithms and Data Structures

CSE 462 Database Concepts

CSE 191/MTH 191 Introduction to Discrete Mathematics

MTH 309 Introductory Linear Algebra

MTH 411 Probability

PHY 107 General Physics I

PHY 108 General Physics II

PHY 158 General Physics Lab PHY 207 General Physics III

*Senior project (may use BPH 458 for this requirement)

Senior Seminar

**Summary**

Total required credit hours for the major (concentration in bioinformatics-biophysics)...99

**See Baccalaureate Degree Requirements for general education and remaining university requirements.**

#### Recommended Sequence of Program Requirements

FIRST YEAR

Fall – CHE 101, MTH 141

Spring – BIO 201, CHE 102, MTH 142, PHY 107

SECOND YEAR

Fall – CHE 203, CSE 115, PHY 108, PHY 158

Spring – BIO 205 or BCH 403; CSE 116, PHY 207

THIRD YEAR

Fall – BIO 302 or BIO 319; BPH 303; CHE 319 or CHE 349; CSE 191/MTH 191

Spring – BPH 405, CSE 250, MTH 309

FOURTH YEAR

Fall – BPH 402, BPH 410, CSE 462, MTH 411

Spring – BIO 400; BPH 458 or Senior Project; senior seminar

### Bioinformatics and Computational Biology - B.S.

### Concentration in Computer Science and Engineering

#### Acceptance Criteria

Minimum GPA of 2.5 overall.

Minimum GPA of 3.0 in the prerequisite courses.

#### Advising Note

Students must maintain a minimum GPA of 3.0 in all major courses to graduate.

#### Prerequisite Courses

BIO 205 Fundamentals of Biological Chemistry

CHE 101 General Chemistry I

CHE 102 General Chemistry II

CSE 115 Introduction to Computer Science

CSE 116 Introduction to Computer Science

MTH 141 College Calculus I

MTH 142 College Calculus II

#### Required Courses

BIO 302 Introduction to Molecular Biology or BIO 319 Genetics

BIO 400 Bioinformatics

CHE 201 Organic Chemistry (LEC only) or CHE 203 Organic Chemistry

CSE 241 Digital Systems

CSE 250 Algorithms and Data Structures

CSE 305 Introduction to Programming Languages

CSE 341 Computer Organization

CSE 396 Introduction to the Theory of Computation

CSE 421 Introduction to Operating Systems

CSE 442 Software Engineering

CSE 462 Database Concepts

CSE 191/MTH 191 Introduction to Discrete Mathematics

CSE 337/MTH 337 Introduction to Scientific Computing or CSE 437/MTH 437 Introduction to Numerical Analysis I *

MTH 241 College Calculus III

MTH 306 Introduction to Differential Equations

MTH 309 Introduction to Linear Algebra

MTH 411 Probability

Senior Project

Senior Seminar

*CSE 438/MTH 438 Introduction to Numerical Analysis II is an optional additional course

**Summary**

Total required credit hours for the major (concentration in bioinformatics-computer science and engineering)...101

**See Baccalaureate Degree Requirements for general education and remaining university requirements.**

#### Recommended Sequence of Program Requirements

**FIRST YEAR**

Fall – CHE 101, CSE 115, MTH 141

Spring – CHE 102, CSE 116, MTH 142

**SECOND YEAR**

Fall – CHE 201 or CHE 203; CSE 191/MTH 191, CSE 241, MTH 241

Spring – BIO 205, CSE 250, CSE 341

**THIRD YEAR**

Fall – CSE 305, CSE 462, MTH 309

Spring – CSE 421, CSE 442, MTH 306

**FOURTH YEAR**

Fall – BIO 302 or BIO 319; MTH 411, Senior Seminar

Spring – BIO 400, CSE 396; CSE 337/MTH 337 or CSE 437/MTH 437; Senior Project

### Bioinformatics and Computational Biology - B.S.

### Concentration in Mathematics

#### Acceptance Criteria

Minimum GPA of 2.5 overall.

Minimum GPA of 3.0 in the prerequisite courses.

#### Advising Note

Students must maintain a minimum GPA of 3.0 in all major courses to graduate.

#### Prerequisite Courses

BIO 205 Fundamentals of Biological Chemistry

CHE 101 General Chemistry I

CHE 102 General Chemistry II

CSE 115 Introduction to Computer Science

CSE 116 Introduction to Computer Science

MTH 141 College Calculus I

MTH 142 College Calculus II

#### Required Courses

BIO 302 Introduction to Molecular Biology or BIO 319 Genetics

BIO 400 Bioinformatics

CHE 201 Organic Chemistry or CHE 203 Organic Chemistry (LEC only)

CSE 250 Algorithms and Data Structures

CSE 462 Database Concepts

CSE 191/MTH 191 Introduction to Discrete Mathematics

MTH 241 College Calculus III

MTH 301 Basic Analysis and Proofs

MTH 306 Introduction to Differential Equations

MTH 309 Introduction to Linear Algebra

MTH 411 Probability

MTH 412 Introduction to Statistical Inference

MTH 418 Survey of Partial Differential Equations

MTH 419 Introduction to Algebra I

MTH 431 Introduction to Real Variables I

MTH 437/CSE 437 Introduction to Numerical Analysis I

MTH 438/CSE 438 Introduction to Numerical Analysis II

Senior Project

Senior Seminar

**Summary**

Total required credit hours for the major (concentration in bioinformatics-mathematics)...103

**See Baccalaureate Degree Requirements for general education and remaining university requirements.**

#### Recommended Sequence of Program Requirements

**FIRST YEAR**

Fall CHE 101, CSE 115, MTH 141

Spring CHE 102, CSE 116, MTH 142

**SECOND YEAR**

Fall CHE 203, CSE 191/MTH 191, MTH 241, MTH 306

Spring BIO 205, CSE 250, MTH 301, MTH 309

**THIRD YEAR**

Fall BIO 302, MTH 411, MTH 419

Spring MTH 412, MTH 418

**FOURTH YEAR**

Fall MTH 437/CSE 437, MTH 431, Senior Seminar

Spring BIO 400, MTH 438/CSE 438, CSE 462, Senior Project

Updated: Nov 16, 2005 10:47:25 AM